"Sexfriend no Senpai The Animation" is an adult-oriented anime series that delves into explicit themes and mature content. Episode 1 introduces Yuuma, a young man who has just enrolled in university. During his welcome ceremony, he meets Nana, an older student from the same university, who shows great interest in him. That same night, when Yuuma returns to his apartment, he is surprised by Nana, who enters with the intention of taking his virginity.